All - Constructed - 1880–1889
| Wood, Theodore, House |
| Woolen Mills Chapel |
| Wright, C. J., House |
| Wright, Ely, House |
| Wright, John R., House |
| Wright Opera house Block Complex |
| Wulff, Capt. N. H., House |
| Wyatt, Leonidas R., House |
| Yankton College Historic District |
| Yardley, John, House |
| Yeakel, Edward, House |
| Yoes, Col. Jacob, Building |
| Yokena Presbyterian Church |
| Yondorf Block and Hall |
| Young Men's Christian Association Building |
| Zachary Railroad Depot |
| Zeitz Buckhorn Exchange |
| Zettler Grocery and Hardware |
| Ziepprecht Block |
| Zinszer's Peter, Mammoth Furniture House |
| Zuhn Building |
Data from United States Park Service and Wikidata
