All - Constructed - 1860–1869
| Serrano, Jose, Adobe |
| Seven Pines National Cemetery |
| Sewall, William, House |
| Sheeley House |
| Shelburne Hotel |
| Shelton, William and Mary, Farmstead |
| Sherman House |
| Shields Woolen Mill |
| Shinkle, Amos, Summer Residence |
| Shortridge High School |
| Sieben, Mrs. Margaret, House |
| Silliman, Arthur, House |
| Silver Lake Schoolhouse #1 |
| Simerly-Butler House |
| Sitka National Cemetery |
| Sledge, James A., House |
| Slifer House |
| Smith, Alvord I., House |
| Smith, Arthur A., Covered Bridge |
| Smith, Benjamin, House |
| Smith, James J. and Anna J. (Linean), House #2 |
| Smith, John, House |
| Smith, Lauritz, House |
| South Carolina Governor's Mansion |
| Southern Minnesota Depot |
| South Fox Island Light Station |
| South Presbyterian Church |
| Spensley Farm |
| Staatz House |
| St. Agnes Cemetery |
| St. Alban's Episcopal Church |
| St. Aloysius-on-the-Ohio |
| Stanley Institute |
| State Asylum for the Deaf,Dumb and Blind |
| State Lunatic Asylum |
| St. Augustine's College Campus |
| St. Charles Seminary and Chapel |
| Stephens Homestead |
| Stevens-Buchanan House |
| Stevens Linen Works Historic District |
| Stewart-Anderson House |
| St. Gregory's Church |
| Stirling |
| St. James Episcopal Church |
| St. John's Episcopal Church |
| St. Joseph's Catholic Church |
| St. Joseph's Catholic Church and Cemetery |
| St. Joseph's Roman Catholic Church |
| St. Luke's Episcopal Church, Chapel, Guildhall, and Rectory |
| St. Luke's Hospital Complex |
| St. Mark's Episcopal Church |
| St. Martin's Catholic Church |
| St. Mary's Church |
| St. Mary's Convent |
| St. Mary's Roman Catholic Church Complex |
| St. Matthias Mission |
| Stonefield |
| Stoutenburgh-Minturn House |
| St. Patrick's Catholic Church |
| St. Patrick's Church |
| St. Patrick's Parish and Buildings |
| St. Paul Catholic Church |
| St. Peter's Church |
| St. Peter's Episcopal Church |
| St. Peter's Episcopal Church |
| St. Peter's Episcopal Church Complex |
| St. Philip's Church in the Highlands |
| St. Rosa Church |
| Sts. Peter & Paul Church and Rectory |
| Sturgeon Point Light Station |
| St. Vrain's Mill |
| St. Wenceslaus Roman Catholic Church |
| Sunderlage Farm Smokehouse |
| Sweeney, J. S., Store, Barn, Livery and Hall |
| Switzerland County Courthouse |
| Taft, Stephen Harris, House |
| Tauy Jones Hall |
| Tevis, D. W. B. and Julia Waddell, House |
| Tharp's Log |
| Thayer House |
| Thoirs, Alexander, House |
| Thompson Block |
| Thompson-Hansen House |
| Thompson Mill Covered Bridge |
| Ticknor, Heman L., House |
| Tipton-Black Willow Ranch Historic District |
| Tipton, Samuel J., House |
| Topsham Fairgrounds Grandstand |
| Tougaloo College |
| Trabing Station-Crazy Woman Crossing |
| Trinidad Head Light Station |
| Trinity Episcopal Church |
| Turnbull, R.P., House |
| Tyron, Augustus S., House |
| Union Bakery |
| Union Block |
| Union Church |
| Union Hall |
| Union Hotel |
| Union League of America Hall |
Data from United States Park Service and Wikidata
