All - Constructed - 1840–1849
| Salisbury, Jonas, House |
| Sands, Hiram, House |
| San Francisco Plantation House |
| Santuit Post Office |
| Scarsdale Railroad Station |
| Scott Farm Historic District |
| Scribner Homestead |
| Seavey, Dr. John B., House and Cemetery |
| Senior Hall |
| Shadyside |
| Shakopee Historic District |
| Shankle, Seaborn M., House |
| Shawnee Mission |
| Shawsheen Cemetery |
| Shrewsbury, Charles L., House |
| Shuford-Hoover House |
| Silver Lake Dam |
| Skinner, Dr. Charles and Susan, House and Outbuildings |
| Sleepy Hollow Cemetery |
| Slingerlands, Albert, House |
| Smith, Archibald, House |
| Smith-Little-Mars House |
| Smith, Marshall, House |
| Smith, Perez, House |
| Smith Shoe Shop |
| Smithsonian Building |
| Smith, William Rankin and Elizabeth Wharton, House |
| Smyth, Benjamin Franklin, House |
| Snow Hill |
| South Manitou Island Lighthouse Complex and Life Saving Station Historical District |
| South Salem Academy |
| Southwest Reef Lighthouse |
| Speed Farm |
| Spratt-Allen-Aull House |
| Spring Side |
| Stacy's Tavern |
| St. Andrew's Episcopal Church and Cemetery |
| St. Ann's Church Complex |
| Stanton, Elizabeth Cady, House |
| Star Hill Plantation Dependency |
| Starrucca Viaduct |
| St. Augustine Church |
| St. Augustine's Catholic Church |
| St. Charles College Historic District |
| Steedman-Ray House |
| Steffens, Joseph, House |
| Sterling, Ella Mahalla Cutter, House |
| Stewart, A. T., Company Store |
| Stewart House |
| St. Frances Methodist Church |
| St. James Episcopal Church |
| St. John`s Catholic Church |
| St. John's Episcopal Church |
| St. Johns Episcopal Church |
| St. John's Roman Catholic Cathedral |
| St. Joseph Church |
| St. Joseph's on the Brandywine |
| St. Joseph's Roman Catholic Church Complex |
| St. Luke's Parish Zion Chapel of Ease Cemetery |
| St. Mark's Episcopal Church |
| St. Martin of Tours Catholic Church |
| St. Mary's Cathedral |
| St. Mary's Catholic Church |
| St. Mary's College |
| St. Matthew's Cathedral And Rectory |
| St. Michael's Cathedral |
| Stockton |
| Stoke |
| Stokenbury Cemetery |
| Stoker House |
| Stone Academy |
| Stone House |
| Stone School |
| Stone Street Cemetery |
| Stony Hill School |
| Stowell, Israel, Temperance House |
| St. Patrick's Pro Cathedral |
| St. Paul's Episcopal Church |
| St. Paul's Union Church and Cemetery |
| St. Peter-In-Chains Cathedral |
| St. Peter's Church |
| St. Peter the Apostle Church and Buildings |
| Summerville Presbyterian Church and Cemetery |
| Sunnyside |
| Surratt, Mary E., House |
| Suttle, Joseph, House |
| Sutton House |
| Swaim House |
| Swan Point Cemetery |
| Sweetser, Warren, House |
| Symmes, Stephen, Jr., House |
| Taft, Zadock, House |
| Taylor-Mayo House |
| Tennessee School for the Deaf Historic District |
| Tenny Castle Gatehouse |
| Thayer, Nathaniel, Estate |
| The Players |
| Thompson Farm |
| Thorbiskope |
| Thornton, Charles Irving, Tombstone |
Data from United States Park Service and Wikidata
